Subsequently, the differential expression of these 18 transcription factors between the control and glomerular FSGS groups was observed in our study, and 9 transcription factors (SMAD3, SIX5, POLR2A, RUNX3, SMC3, EGR1, TP53, JUND, and MAX) were obtained. The gene discussed is TP53; the disease is focal segmental glomerulosclerosis.