There is now accumulating evidence suggesting that individuals who are overweight or obese and have insulin resistance, defined as metabolically unhealthy, are at elevated risk of cardiovascular disease, compared to normal‐weight individuals with normal insulin levels; however, those who are overweight or obese, but who have normal insulin sensitivity (defined as metabolically healthy) have little risk.21, 24, 25, 26. Here, INS is linked to cardiovascular disorder.