Premised upon preclinical studies detecting a causal role of SARS CoV2 on NET-formation [8] and NET-forming neutrophils on capillary-tissue barriers, [8, 9]this prospective study of patients with acute COVID-19 identified DEspR + [NET + Ns] as a mediator of multi-organ failure progression. Here, FBXW7-AS1 is linked to COVID-19.