Here, we test whether the putative “rogue” CD11b + DEspR + NET-forming neutrophil-subset, DEspR + [NET + N], mediates the worsening of early multi-organ dysfunction (measured by the Sequential Organ Failure Assessment [SOFA]-score [21] at timepoint-1) towards multi-organ failure (measured as higher SOFA-scores at a later timepoint-2), and/or mediates poor clinical outcomes (as measured by intensive care unit free days [ICUFD] by day-28) [22] in severe COVID-19 using causal mediation analysis. Here, FBXW7-AS1 is linked to COVID-19.