Our recent studies have identified DEspR + CD11b + neutrophils (DEspR + [Ns] from hereon), as a dysregulated “rogue” neutrophil-subset capable of NET-formation while in the circulation, extended survival, low-clearance, enhanced adhesion, and association with severity measures and mortality in COVID-19 acute respiratory distress syndrome (ARDS) [18–20]. The gene discussed is ITGAM; the disease is acute respiratory distress syndrome.