For OS in CRC patients, N stage (2), metastasis, and LARS high/DKK4 low expression were independent poor prognostic factors (HR = 3.66, 95% CI: 1.69–7.94, p = 0.001; HR = 4.92, 95% CI: 1.95–12.39, p = 0.001; and HR = 2.75, 95% CI: 1.21–6.25, p = 0.015, respectively; Table 5). Here, LARS1 is linked to colorectal carcinoma.