DKK4 and neoplasm: For DFS in CRC patients, tumor invasion and LARS high/DKK4 low expression were independent poor prognostic factors (HR = 3.14, 95% CI: 1.27–7.76, p = 0.013; HR = 3.04, 95% CI: 1.52–6.09, p = 0.002, respectively; Table 6).