Meanwhile, the OS and DFS of the DKK4 high expression group (494 cases) were significantly higher than those of the DKK4 low expression group, but the Cox regression analysis showed that only N stage (stage 2), LN metastasis, and metastasis were independent poor prognostic factors of OS in CRC patients, and DKK4 expression alone was not an independent prognostic factor of OS. This evidence concerns the gene DKK4 and colorectal carcinoma.