Consistent with the previous in vitro findings, skin-specific overexpression of TSLP spontaneously leads to an AD-like phenotype, accompanied with an increase of inflammatory cell infiltration in eczematous lesions, elevated frequency of CD4+ Th2-expressing cutaneous homing receptors, and higher levels of IgE in serum in comparison with WT littermates [50]. This evidence concerns the gene IGHE and Alzheimer disease.