Sema4D expressed on many cancer cells, Plexin-B1 also expression in cancer such as ovarian, melanoma, when Sema4D combined with Plexin-B1, it correlates with tumor immune infiltration, angiogenesis, and tumor progression in melanoma (Ch’ng & Kumanogoh, 2010; Lu et al., 2021). The gene discussed is PLXNB1; the disease is cancer.