In this study, we used immunohistochemical analysis, and several bioinformatic databases, such as gene expression profiling interactive analysis (GEPIA), UALCAN, cBioPortal, WebGestalt, and Metascape, to analyze the function of SIRT5 and other six SIRT family members in ccRCC, which could be helpful in finding new strategies for ccRCC treatment. The gene discussed is SIRT5; the disease is nonpapillary renal cell carcinoma.