By using univariate analysis, aberrant expression of SIRT5 in ccRCC was closely related with pathological grading and cancer size with significant statistically difference (p < 0.05), among them, the p-value of 0.0614 was greater than 0.05 under the chi-square test for pathological grading index, but this study was based on a small sample, so the p-value of 0.0487 from Fisher’s exact test was adopted. This evidence concerns the gene SIRT5 and nonpapillary renal cell carcinoma.