Based on experiments (IHC) and data analysis, we speculated that the expression of SIRTs may be important for ccRCC, among them, SIRT4 and SIRT5 (particularly) could be involved in inhibiting the progression of ccRCC, whereas SIRT6 and SIRT7 are speculated to be important for promoting ccRCC development. The gene discussed is SIRT5; the disease is nonpapillary renal cell carcinoma.