Male APP/PS1 transgenic mice display reduced insulin sensitivity compared to littermates at 2 months of age (Macklin et al., 2017) and impaired glucose tolerance at 2, 5, 9, and 13 months but not at 15–18 months of age despite no significant changes in glycemic response to insulin being reported at these later time points (Denver et al., 2018; Kim et al., 2021; Macklin et al., 2017; Mody et al., 2011). Here, INS is linked to Impaired glucose tolerance.