PSEN1 and Alzheimer disease: Double transgenic APP/PS1 overexpressing mice show diminished glucose tolerance and insulin sensitivity before cognitive impairment that coincides with amyloid‐β plaque formation (Macklin et al., 2017), and 3xTg‐AD mice display disrupted central insulin signaling along with reduced glucose tolerance and elevated body weight in adulthood (Velazquez et al., 2017).