PSEN1 and Alzheimer disease: To this end, we employed the TgF344‐AD transgenic rat model which expresses both mutant human amyloid precursor protein (APPSW) and presenilin 1 (PS1ΔE9), resulting in the recapitulation of age‐dependent AD pathology including elevated soluble amyloid‐β, hyperphosphorylated tau, neuronal loss, and gliosis as early as 6 months of age.