DSG2 and COVID-19: Levels of DSG2 IgG autoantibodies were significantly elevated in sera from both acute (median OD = 0.90[0.60–1.26], n = 39, P<0.0001) and convalescent (median OD = 1.10[0.85–1.48], n = 25, P < 0.0001) COVID-19 cohorts following severe disease when compared with healthy controls (median OD = 0.35 [0.22–0.48], n=50) (Fig. 2).