However, the percentages of CD3+CD4+, CD3−CD19+, and CD19+CD23+ lymphocytes and the CD4+/CD8+ ratio were lower in the atypical EBV infection, EBV-IM1, and EBV-IM2 groups than those in the EBV-RTI, AURI, and control groups (P < 0.01). This evidence concerns the gene CD4 and Epstein-Barr virus infection.