In agreement with our previously published data [21], publicly available gene expression data from the Cancer Genome Atlas (TCGA) revealed that expression of GPNMB, a transcriptional target of TFE3, was significantly higher in TFE3-fusion RCC compared to clear cell RCC, papillary RCC or normal kidney [8, 35] (Supplementary Figure S7). This evidence concerns the gene TFE3 and renal cell carcinoma.