Consistently, comparing the RNAi and CRISPR TP53-codependency scores of ATM versus USP28 shows a more robust effect of the USP28 knockout (USP28 RNAi codependency score p = 4.9e-112 versus ATM p = 3e-80, in a pan-cancer analysis; Additional file 1: Fig. S5b). This evidence concerns the gene USP28 and cancer.