For most of the tested drugs (105 out of 188 drugs that were significantly associated at < 25% FDR, pan-cancer), the associations with TP53 had a lower FDR when testing using TP53 phenocopy score, over when using the TP53 CFE labels (denoting TP53 mutations which alter gene function) (Fig. 4c, effect size at Additional file 1: Fig. S7b). This evidence concerns the gene TP53 and cancer.