Consistently, comparing the RNAi and CRISPR TP53-codependency scores of ATM versus USP28 shows a more robust effect of the USP28 knockout (USP28 RNAi codependency score p = 4.9e-112 versus ATM p = 3e-80, in a pan-cancer analysis; Additional file 1: Fig. S5b). The gene discussed is TP53; the disease is cancer.