HMGB2 and acute lymphoblastic leukemia: As shown in Fig. 1G, B cell populations from B-ALL patients significantly elevated the expression of immunoglobulin heavy constant alpha-1 (IGHA1), immunoglobulin kappa constant (IGKC), immunoglobulin lambda constant 2 (IGLC2), immunoglobulin lambda constant 3 (IGLC3), marginal zone B and B-1 cell-specific protein (MZB1), high mobility group box 2 (HMGB2), and lysozyme (LYZ).