CD22 and precursor B-cell acute lymphoblastic leukemia: As a result, nuclear factor kappa-B (NF-κB), CD19, and Bruton’s tyrosine kinase (BTK), rather than CD22 and AKT serine/threonine kinase 1 (AKT1), were highly expressed in GSDMD-positive pre-B cells during the progression of B-ALL (Fig. 3H, I).