POLE and hereditary cancer: Here, 10 patients (46%; 10/22) had 17 candidate variants in 14 genes currently associated with hereditary cancers across major organ systems (ATM, BRCA2, POLD1, POLE, FH, MITF, MSH3, MUTYH, PDGFRA, RET, SDHB, SMARCA4, SMARCE1, TSC2).