Here, 10 patients (46%; 10/22) had 17 candidate variants in 14 genes currently associated with hereditary cancers across major organ systems (ATM, BRCA2, POLD1, POLE, FH, MITF, MSH3, MUTYH, PDGFRA, RET, SDHB, SMARCA4, SMARCE1, TSC2). Here, SMARCE1 is linked to hereditary cancer.