Here, 10 patients (46%; 10/22) had 17 candidate variants in 14 genes currently associated with hereditary cancers across major organ systems (ATM, BRCA2, POLD1, POLE, FH, MITF, MSH3, MUTYH, PDGFRA, RET, SDHB, SMARCA4, SMARCE1, TSC2). Here, SMARCA4 is linked to hereditary cancer.