Hence, we focused on the alteration of STAT3 in the tubular cells of the LPS-induced AKI model and found that 4-OI could suppress the upregulation of LPS-induced p-STAT3(Y705) and p-STAT3(S727) to protect renal tubular cells in the septic state (Fig. 5). The gene discussed is STAT3; the disease is acute kidney injury.