To determine how the neuronal MEF2C transcription network is affected by IFN-I hyperactivation, we examined a published snRNA-seq dataset of RNaseT2−/− mice, a model of infantile-onset RNaseT2-deficient leukoencephalopathy with severe IFN-I neuroinflammation and cognitive impairment44. The gene discussed is MEF2C; the disease is Leukoencephalopathy.