To determine how the neuronal MEF2C transcription network is affected by IFN-I hyperactivation, we examined a published snRNA-seq dataset of RNaseT2−/− mice, a model of infantile-onset RNaseT2-deficient leukoencephalopathy with severe IFN-I neuroinflammation and cognitive impairment44. This evidence concerns the gene RNASET2 and Leukoencephalopathy.