To assess cGAS in tauopathy in vivo, we crossed P301S transgenic mice with Cgas–/– mice to generate transgenic and non-transgenic litters expressing two, one or no copies of functional Cgas. We performed snRNA-seq of hippocampi from 8- to 9-month-old Cgas+/+, P301SCgas+/+, P301S Cgas+/– and P301S Cgas–/– mice. Here, CGAS is linked to tauopathy.