However, normal glial cells and glia-like tumor cells have their specific lineage-associated genes, such as FABP7 and MSX1 in normal ASCs, OLIG2 and OPCML in normal OPCs and OLs, FRMD5 in ASC-like ependymomas and GLUL in OPC/OL-like ependymomas (Fig. 6q,r and Supplementary Fig. 6b). Here, FRMD5 is linked to ependymoma.