SIRT2 is localized in the cytoplasm of both neurons and oligodendrocytes [60], and the well-known substrate of SIRT2 is α-tubulin, an important component of microtubule cytoskeleton whose acetylation by SIRT2 is linked to brain aging and neurological disorders [61] such as AD [62, 63] and PD [64, 65]. Here, SIRT2 is linked to Alzheimer disease.