ACE and Renal insufficiency: No significant differences in age, gender, height, body weight, cardiovascular risk factors (hyperlipidemia, hypertension, diabetes mellitus, smoking, and renal insufficiency), or previous drug therapy (anti-platelet medication, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers [ACEIs/ARBs], β-blockers, calcium channel blockers [CCB], and statins) were detected between the BUDO and BUDAO groups (P > 0.05) (Table 1).