The TRAMP mouse [44–47], one of the most widely accepted in PCa research [48], inactivates pRB via the SV40 Large T antigen, and recapitulates with ~100% penetrance multiple aspects of the human disease, including prostatic intraepithelial neoplasia (PIN) lesions and multifocal invasive carcinoma, and emulates histological and molecular events of human PCa [49]. The gene discussed is RB1; the disease is posterior cortical atrophy.