GISTIC2 analysis identified 51 (10%) ‘deep’ (i.e., homozygous) deletions of DACH1. In six distinct cohorts, homozygous deletions of DACH1 were identified in between 3 and 18% of prostate cancers (Fig. 1C, Supplementary Fig. S1). Here, DACH1 is linked to Familial prostate cancer.