DACH1 was detectable in human PCa cell lines (Fig. 4E, F), including PC3 cells, in which TGFβ induced EMT, as evidenced by induction of the mesenchymal marker vimentin (Fig. 4G), and an increase in the proportion of cyclin D1 located in the cytoplasm. Here, CCND1 is linked to posterior cortical atrophy.