This study investigated the expression levels of eight NSCLC-associated genes, including Dual-specificity phosphatase 6 (DUSP6), Eukaryotic translation initiation factor 2 subunit gamma (EIF2S3), Growth factor receptor bound protein 2 (GRB2), MDM2 proto-oncogene (MDM2), Neurofibromin 1 (NF1), DNA polymerase delta interacting protein 2 (POLDIP2), Ring finger protein 4 (RNF4), and WEE1 G2 Checkpoint Kinase (WEE1)20, for their ability to differentiate between MPE and benign pleural effusion. The gene discussed is GRB2; the disease is non-small cell lung carcinoma.