ZAP70 and cholangiocarcinoma: Other highly significant adaptive pathways relate to T-cell receptor-induced activation of cytotoxic T-cells and have not been described in cholangiocarcinoma including cluster of differentiation 3 (CD3) phosphorylation (FDR 0.009), translocation of zeta-chain associated protein kinase 70 (ZAP70) to the immunological synapse (FDR 0.039) and the TH1TH2 pathway (FDR 0.02).