Mice receiving donor bone marrow (BM) cells transduced with BCR-ABL-Cre-GFP developed CML much faster than those receiving bone marrow cells transduced with BCR-ABL-GFP, and further blocked imatinib effect on survival of CML mice (Fig. 3B). The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.