To elucidate the function of TXNIP in malignant hematopoiesis, we firstly generated a mouse CML model with BM transduction and transplantation by using TXNIP conditional knock mice (TXNIPfl/fl) and BCR-ABL-Cre-GFP retrovirus (Supplementary Fig. 2A) [26]. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.