Similar to in Bcs1lp.S78G;mt-Cyb p.D254N  mice, AOX also prevented the hepatic induction of γH2AX and CDKN1A, and attenuated the liver disease in the juvenile (P35) Bcs1lp.S78G mice (Supplementary Fig. 5a, c–e). Here, CDKN1A is linked to liver disorder.