When the IL6 gene was identified as possibly influencing SSc development and progression, analyses identified a substantial association between the minor allele of rs2069840 and limited cutaneous SSc, a trend in association for the minor allele rs1800795 and diffuse cutaneous SSc, and an association with overall SSc and the triplet rs2069840-rs1800795-rs206982721. This evidence concerns the gene IL6 and systemic sclerosis.