STAT3 and neoplasm: Suspended in the peritoneal cavity, tumor cells face different challenges, like anoikis, which can be prevented by cell cluster (spheroid) formation, maintenance of mesenchymal and stemness state (e.g. via STAT3 signaling) and/or survival signaling like PI3K, MEK–ERK, or TNF–TNFR2–NF-κB3,12.