Although the reduction of IDOL was associated with increased LDLR expression and intracellular lipid accumulation in individuals with diabetes, the relative contribution of IDOL and LDLR-mediated lipoprotein uptake to intracellular lipid accumulation in macrophages still needs to be further evaluated since we have not measured scavenger receptor expression and modified lipoprotein uptake in our study. Here, LDLR is linked to diabetes mellitus.