This included pathways (e.g. Wnt signaling pathway, PI3K-Akt signaling pathway, Notch signaling pathway) that are on one hand crucial regulators of cellular homeostasis, survival and growth, and on the other are potential drivers of disease (e.g. different types of cancer, neurodegenerative disease, cardiovascular disease). This evidence concerns the gene AKT1 and neurodegenerative disease.