MAPT and Alzheimer disease: In the AD network, irrespective of brain regions, genes JMJD6, SLC5A3, CIRBP, TARBP1 and AHSA1 are among the top ten central genes correlated with the SSG set, of which AHSA1 (activator of HSP90 ATPase activity 1) is already known to correlated with AD progression by promoting tau fibril formation [71].