The synergistic action of reduced miRNAs and increase in their target mRNAs, such as Unc5c (Latil et al, 2003), Thsd4 (Wu et al, 2020), Sparc (de Oliveira‐Barros et al, 2021), Runx1t1 (Kan et al, 2010) and Pcdh17 (Costa et al, 2011), known to promote prostate cancer, may contribute further to the prostate lesions and tumours in the A537T‐TRAMP mice (Fig 6E). This evidence concerns the gene THSD4 and Familial prostate cancer.