We used CRISPR‐Cas9 genome editing to introduce the Ala541Thr variant in the conserved mouse Elac2 gene, used homologous recombination to generate a prostate‐specific deletion of Elac2 and bred these lines onto the transgenic adenocarcinoma of mouse prostate (TRAMP) model that carries the simian virus 40 (SV40) T antigens under control of the probasin (Pb) promoter (Greenberg et al, 1994; Gingrich et al, 1999). This evidence concerns the gene ELAC2 and adenocarcinoma.