RNASEL and Familial prostate cancer: The hereditary prostate cancer 1 gene (HPC1)/Ribonuclease L (RNASEL; Carpten et al, 2002; Rökman et al, 2002; Agalliu et al, 2010; 1q24–25) and HPC2 or ElaC Homolog Protein 2 (ELAC2; 17p12; Rebbeck et al, 2000; Tavtigian et al, 2001; Adler et al, 2003) are the most relevant candidate genes for prostate cancer predisposition (Alvarez‐Cubero et al, 2015).