RPPA analyses supported the histological findings revealing increases in protein markers of tumorigenesis onset at 10 weeks of age (including FAK, EGFR and JNK2) and most remarkably cancer progression at 30 weeks of age with the greatest and consistent increases in MYC and concomitant reduction in PTEN levels in the KO‐TRAMP and A537T‐TRAMP mice, compared with WT‐TRAMP mice (Fig 3D and E, and Appendix Fig S3D and E; Miller et al, 2012; Yi et al, 2019; Rebello et al, 2021). Here, PTEN is linked to cancer.