This difference may account for the increased tumour formation in the prostates of the A537T‐TRAMP, where semaphorins and Nox4 were increased, compared with the KO‐TRAMP mice, as these proteins can contribute to more invasive prostate cancer (Blanc et al, 2011; Roy et al, 2015; Liu et al, 2015a; Williamson et al, 2016; Peacock et al, 2018; Yin et al, 2021). This evidence concerns the gene NOX4 and Familial prostate cancer.