IGF1 and medical procedure: The main differences between the 30‐week‐old KO and A537T mice independent of the TRAMP background were predominately the activation of transport and RNA processing pathways in KO/KO‐TRAMP mice and an upregulation in cell cycle and cell growth processes via WNT signalling and IGF transport and uptake in A537T/A537‐TRAMP mice, reflective of prostate tumorigenesis and cancer progression compared with prostate enlargement in the KO and A537T mice (Appendix Fig S7B and D).