The level of serum albumin was lower (p = 0.002), and the levels of bone metabolism markers, including intact PTH (p < 0.001), sALP (p < 0.001), ß-CTX (p = 0.01), and P1NP (p < 0.001), were significantly higher in osteoporosis patients. The gene discussed is KHDRBS3; the disease is osteoporosis.