As the uptake into hepatocytes and the secretion into bile are mediated by OATP uptake transporters and MRP2 efflux transporters, respectively, these processes are highly time-dependent, impacted by co-morbidities (e.g., liver disease) and the use of medication that compete with the contrast agents for the hepatocyte uptake transporters (e.g., statins) [20, 21]. This evidence concerns the gene ABCC2 and liver disorder.