Besides, mutations of BCR/PI3K signaling intermediates (RHOA, GNA13, and SGK1) and NF-kB modifiers (CARD11, NFKBIE, and NFKBIA) were also found to be enriched in cluster 4 subtype of DLBCL, which is primary GCB DLBCL (Chapuy et al. 2018). This evidence concerns the gene RHOA and diffuse large B-cell lymphoma.