CDKN2A and neoplasm: Notably, there were no significant differences in tumor purity between CDKN2A homodel and heterodel cases in any cohort (Supplementary Figure 1a–c). Three different patterns of CDKN2A/B loss were noted in both the homodel and heterodel groups: (1) focal loss of only the CDKN2A/B locus without loss of 9p, (2) loss of the CDKN2A/B locus along with a segment of 9p, and (3) loss of the entire 9p arm including the CDKN2A/B locus (Supplementary Fig. 2a–e).