KDM6B and childhood gender nonconformity: However, chromatin regulators including KDM6B have scaffolding functions as well as enzymatic functions (Kim et al., 2013; Kim et al., 2018; Miller et al., 2010; Ohguchi et al., 2017; Xun et al., 2017), thus we attempted to use pharmacological inhibition of KDM6B to validate the role of its enzymatic activity in developing CGN gene regulation.