ACTA1 and Chronic colitis: Fibrosis is a common feature in the chronic colitis and is characterized by excessive deposition of extracellular matrix, such as collagens, in the intestine.[38, 39] A variety of cell types are involved in the development of fibrosis, including intestinal subepithelial myofibroblasts and smooth muscle cells which express α‐SMA.[40] To investigate the influence of Zein/SA/BG microspheres on the fibrotic condition, immunostaining of α‐SMA was performed (Figure 8B).