Although the inflammation caused by DSS is not exactly the same as the inflammation seen in the IBD patients, DSS‐induced mice are still the most commonly used inflammation model to investigate IBD.[49] In our DSS‐induced mice model, destruction of the epithelial tissue barrier, tissue swelling, weight loss, and accumulation of M1 macrophages were observed, which is consistent with the clinical symptoms of IBD.[49] Following treatment of Zein/SA/BG microspheres, reconstruction of the ZO‐1 protein layer in the epithelial tissue was observed. Here, TJP1 is linked to inflammatory bowel disease.