Myeloid cells, especially tumor‐associated macrophages (TAMs), are one of the most abundant immune cell types in PCa.[10] Previous studies have shown that TAMs inhibit the proliferation of CD8+ T cells in breast cancer,[11] induce PD‐L1 expression to inhibit antitumor activity of T cells in hepatocellular carcinoma,[12] and recruit regulatory T cells to tumor microenvironment in colorectal cancer and melanoma,[13] thereby exert immunosuppressive effects that limit the efficacy of ICB. This evidence concerns the gene CD8A and neoplasm.