It is worth noting that TEX can induce immunosuppression by suppressing the functions of T cells and NK cells and altering the numbers or activities of immune suppressor cells, including regulatory T cells (Tregs) and myeloid‐derived suppressor cells (MDSCs) in the tumor microenvironment (TME).[18, 19, 20] Moreover, TEX can help cancer cells escape from immune surveillance in HNSCC, thereby promoting tumorigenesis.[21, 22] Therefore, as a TAA, TEX should take advantage of its immunogenicity and inhibit its immunosuppressive effect. This evidence concerns the gene TEX46 and head and neck squamous cell carcinoma.