Thus, OXPHOS depression may serve as a better strategy to sensitize tumor radiotherapy by enhancing the DNA damage generation through reversing tumor hypoxia, inhibiting the DNA repair process by reducing the intracellular PD‐L1 expression, and depressing the membranal PD‐L1 expression via disrupting PD‐1/PD‐L1 axis recognition. This evidence concerns the gene CD274 and neoplasm.