Currently, some small molecules that clear both tumor membranal and intracellular PD‐L1 may serve as more potent PD‐L1 inhibitors.[8, 25] As proved before, the small‐molecule anti‐tumor drug LND plays an anticancer role mainly by affecting the energy metabolism of cells.[26] Nevertheless, its regulation of PD‐L1 protein expression in lung cancer cells has not been thoroughly studied. Here, CD274 is linked to lung cancer.