Furthermore, in an effort to explore whether the binding force of PD‐L1 on the tumor membrane and PD‐1 on T cells was affected by TPP‐LND@Lip, the mouse PD‐1(CD279) Fc protein was used.[19] As the results of the immunofluorescence staining assay showed, the binding force of PD‐L1 on the tumor membrane with PD‐1 was significantly reduced after treating with TPP‐LND@Lip (Figure 4F and Figure S20, Supporting Information). This evidence concerns the gene PDCD1 and neoplasm.