CD274 and lung cancer: Under the action of SEL1/Hrd1 ubiquitination, PD‐L1 with S195‐p is degraded by the proteasome, the membranal and intracellular expression of which decreased at last.[11] Therefore, OXPHOS inhibition may be used as a novel membranal and intracellular PD‐L1 depression strategy to improve the efficacy of radiotherapy in lung cancer treatment.