In light of our previous data associating increased IL-6 family pro-inflammatory cytokine levels with CC induced by tumor STK11/LKB1 loss of function, we next determined if the JAK inhibitor ruxolitinib could block cachexia-induced adipose wasting in vivo observed with allotransplantation of the parental human NSCLC STK11-variant H1573 line into mice. This evidence concerns the gene IL6 and non-small cell lung carcinoma.