STK11 and Cachexia: Specifically, there was an approximately 75% reduction in adipocyte cross-sectional area (Supplemental Figures 4, B and C) and an approximately 25% reduction in myofiber cross-sectional area (Supplemental Figures 4, E and F) in tissues from mice bearing cachexia-inducing STK11-silenced MC38 tumors when compared with mice bearing non–cachexia-inducing MC38 parental tumors.