Therefore, the patients (n = 40) with sera devoid of anti-β2m-IgM or IgG may represent those in early stages of RA, and the 15 patients sera with anti-β2m-IgM or anti-β2m IgG may represent advanced phases of immunological progression of RA, as summarized in Table 11. Here, CD40LG is linked to rheumatoid arthritis.