Examples of subunit vaccine shaving the S protein as an antigen are the SCB-2019 vaccine by Clover Biopharmaceuticals AUS Pty Ltd., Chengdu, Sichuan, China, NVX-CoV2373 by Novavax, Covax-19 by GeneCure Biotechnologies; Vaxine Pty Ltd., Adelaide, Australia and MVC-COV1901 by Medigen Vaccine Biologics Corp. Whereas subunit vaccines with the RDB domain of the S protein as an antigen include KBP-COVID-19 by Kentucky BioProcessing, Inc and the vaccine from Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd., Anhui, China. This evidence concerns the gene PROS1 and COVID-19.