In the meantime, we found that except for KRT24 and CRCT1 (AUCs <0.75), the other eight genes yielded a high predictive performance for the occurrence of HNSCC, with AUC values of 0.828 (PPL), 0.804 (SECL), 0.854 (KRT4), 0.799 (KRT78), 0.824 (KRT13), 0.797 (SPRR3), 0.822 (TGM3), and 0.852 (CRNN; Figure 6A–J, right). This evidence concerns the gene SPRR3 and head and neck squamous cell carcinoma.