Analysis of the Ye Head‐Neck (Figure 10A–C) and Peng Head‐Neck (Figure 10D–F) datasets showed that the expression levels of KRT13 (p < .001), KRT78 (p < .001), and SPRR3 (p < .001) in HNSCC were significantly lower than in normal tissues. This evidence concerns the gene KRT78 and head and neck squamous cell carcinoma.