With regard to Aβ production, TAX inhibited Aβ production by suppressing the ApoE-extracellular signal-regulated kinase 1/2-amyloid precursor protein axis in cerebral amyloid angiopathy model mice [14], and activated Janus kinase 2/signal transducer and activator of transcription 3, and nuclear factor kappa B signaling via sirtuin 1 activation in an in vitro study, leading to suppressed β-secretase 1 expression [26]. This evidence concerns the gene APOE and cerebral amyloid angiopathy.