MAPT and Alzheimer disease: The lipid per oxidation indicators 4-hydroxynonenal and malondialdehyde are found in the cerebral cortex and hippocampus regions of AD patients.19–21 AD is associated with the formation of neuro fibrillary tangles which are composed of Tau protein, senile plaques made up of amyloid beta protein and there is substantial loss of cholinergic and cortical neurons.22,23 Many evidence shows that loss of acetylcholine a cholinergic neurotransmitter is responsible for the cognitive impairment.