ACHE and Cognitive impairment: Currently available AD dugs are mainly used to manage the symptoms of AD, for example at present the acetylcholine esterase inhibitors were currently used to manage the cognitive deficits of AD.26 Various studies show that treatment with antioxidants reduced the toxic effects of β-amyloid and improve cognitive function in experimental animals.27–31 So, AChE and oxidative stress might be attractive target for the drug discovery for AD.