EGFR and lung cancer: 10 Many genetic alterations have been shown to be in related to lung cancer such as activation of epidermal growth factor receptor (EGFR), 11 mutation of Kirsten rat sarcoma viral oncogene homolog (KRA) or a tumour suppressor gene such as TP53 12, and the loss of the retinoblastoma protein (RB1) gene in the lungs. 13