NEDD4 and hypertensive disorder: Proteins previously implicated in protein homeostasis failure associated with neurodegenerative and/or CVDs, such as CAND1, SerpinH1, NEDD4, UCP1, Plectin-1, 14-3-3[155], ApoE, Cardiac Phospholamban, and HSP-90[156], were shared in common between MI, aging, and hypertension — suggesting that these conditions accrue protein aggregates due to defects in the same or similar pathways [Figure 1].