IFNγ or CAR-T10%MYXV decreases the activity of AKT, which regulates autophagy through phosphorylating Beclin 1 (Wang et al., 2012), while overexpression of constitutively active AKT in cancer cells abolishes the antitumor activity of CAR-T10%MYXV and VPS34 level (Zheng et al., 2022). The gene discussed is BECN1; the disease is cancer.