PIK3C3 and cancer: Since SKP-1 mediates ubiquitination and degradation of VPS34 (Xiao et al., 2015) and interacts with MYXV-derived M-T5 protein (Werden et al., 2009), VPS34 level and antitumor activity of CAR-T10%MYXV or MYXV are reduced by overexpression of SKP-1 in cancer cells (Zheng et al., 2022).