Aberrant expression of FAM3C protein, encoded by interleukin-like EMT inducer (ILEI), in NSCLC tumors enhances cell transformation and stimulates distant lung tumor colonization, and a study on mice demonstrated that FAM3C is an oncogenic factor and a driver of distant metastasis in NSCLC (Thuya et al., 2023). This evidence concerns the gene FAM3C and non-small cell lung carcinoma.