Previous research showed that in hypoxic microenvironments, TWIST transcription factor interacts with NRPI to elevate SEMA3C expression (Yang et al., 2022), which promotes tumor cell angiogenesis and perineural invasion, suggesting that SEMA3C may mediate a key gene for immunosuppression under hypoxic microenvironment. The gene discussed is SEMA3C; the disease is neoplasm.