caf_C2_scissor may be closer to the antigen-presenting CAF phenotype, which are similar to antigen-presenting CAFs and can activate CD4+ T-cell in an antigen-specific manner confirming their immunomodulatory capacity, similar in function to the C2 subtype of Scissor_C2 tumor cells (Figures 10B, C). This evidence concerns the gene CD4 and neoplasm.