On the contrary, osteoblasts are known to release abundant regulatory factors (e.g., RANKL (Panizo et al., 2009), osteopontin (Cho et al., 2009), and osteoprotegerin (OPG) (Rochette et al., 2019)) that also act on blood vessels, and the common agents (estrogen (Wu et al., 2020), parathyroid hormone (Shao et al., 2003), etc.) for osteoporosis also accompany an inhibition of VC. Here, TNFRSF11B is linked to osteoporosis.